Dear Editor – I write in response to the article on March 8, 2022 in the Solomon Star titled “DR WHO OPPOSES VACCINATION”.
The Solomon Star article claimed as proof the Lund University publication by Markus Alden et al titled “Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line.”
Whilst molecular biology is tough for lay people to understand, the following simplified points should make us wary of making unwarranted conclusions that Alden et al themselves did not reach:
1. they subjected Huh7 cell lines (human liver cancer cells with accelerated mitotic activity) to Pfizer mRNA vaccine not stable human cells
2. they did the study “in vitro” i.e., they used laboratory machinery not an “in vivo” study i.e., using normal animal or normal human subjects
3. they demonstrated long interspersed nuclear element-1 (LINE-1) protein increase in the nucleus. However, LINE-1 is already high in cancer cells and less so in stable human cells
4. the rise of ORF1 (open reading frame 1) levels in the Huh7 cell nucleus is not conclusive proof of nuclear entry by the Pfizer mRNA-derived protein as the cancer cells used already have own LINE-1 protein. A better strategy would have been for Alden et al to
demonstrate ORF1-Pfizer-derived LINE-1 protein complex nuclear entry
5. Alden et al themselves concluded that they “do not know if DNA reverse transcribed from BNT162b2 (i.e., Pfizer mRNA) is integrated into the cell genome”
In summary, although Alden et al from Lund University conclusively found DNA reverse transcribed from mRNA in both the cytosol and nucleus, unlike the Solomon Star article, they did not see “permanent alteration of the genetic code, within hours” through “integration” into the human ngenome.
This claim by the Solomon Star article is unsupported by the Alden et al research findings.
Dr James Auto
Paediatrician/Chief Medical Officer,
CWM Hospital, Fiji
